Explore the Agenda
7:30 am Check-In & Coffee
Welcome to the 10th Anniversary CAR-TCR Summit Europe. Collect your badge, settle in with a coffee, and reconnect with the community before two days of learning, collaboration and partnerships.
8:30 am 10th Anniversary Welcome Remarks
8:45 am Industry Leader’s Fireside Chat: Aligning the Future of In Vivo & Ex Vivo Cell Therapies for Greater Clinical & Commercial Impact
- Reviewing how emerging clinical data is shaping market perspectives on in vivo cell therapies to guide smart pipeline decisions
- Examining the resurgence of next-generation in vivo CAR-Ts and ex vivo explorations for solid tumours and autoimmune disease to identify where each modality can unlock the greatest opportunity
- Aligning scientific, manufacturing, regulatory and commercial perspectives on the future direction of the field to accelerate clinical impact
9:30 am Keynote Presentation: Building Novel Dual-Action CAR-Ts to Effectively Balance Safety & Efficacy
- Highlighting dual-action CAR targeting the microenvironment and tumour cells
- Targeting macrophages to overcome immunosuppression in solid brain tumours
- Sharing emerging clinical data to evaluate the safety, efficacy, and reliability of CAR-T approaches
10:00 am Coffee Break & Networking
As the community unites, gain valuable networking time with Europe’s leading cell therapy experts, follow up with the morning’s speakers for insights beyond the presentation slides and forge valuable new and lasting connections.
Preclinical Innovation
Leveraging Ex Vivo Therapeutic Success to Refine In Vivo Development Decision Making & Accelerate the Path to Clinic
11:00 am Presentation Details to be Announced
11:30 am Harnessing CAR-Macrophages to Overcome Solid Tumour Barriers In Vivo
- Exploring CAR-Macrophages as an alternative cell platform to overcome the limitations of CAR-T therapies in solid tumours
- Leveraging innate immune functions to penetrate the tumour microenvironment, enhance tumour infiltration, and drive durable responses
- Demonstrating the preclinical potential of in vivo cell therapy approaches to enhance accessibility for solid tumours
12:00 pm Panel Discussion: Progressing Ex Vivo Success into Effective In Vivo Therapies
Applying key learnings from ex vivo developments to optimise indication selection, targeting strategies, and clinical translation for in vivo approaches
Discussing the key scientific, regulatory considerations to streamline the integration of in vivo cell therapies into the pipeline
Clinical & Manufacturing Strategy
Harnessing Global Regulations & Manufacturing Opportunities to Efficiently Scale Cell Therapies
11:00 am Accelerating Global Clinical Development Through Smarter Regulatory Strategy
- Navigating FDA, EMA, and NMPA expectations early to align development plans and enable smoother clinical progression
- Leveraging IND, CTA and IIT pathways to optimise streamline approvals, and reduce patient enrolment timelines
- Learning from successful global development programmes to identify regulatory strategies that have accelerated approvals, site activation, and clinical execution across major markets
11:30 am Harnessing the Best of East & West to Accelerate Global Cell Therapy Development
- Identifying the operational, strategic, and partnership frameworks required to leverage China’s pace and cost advantages while meeting the expectations of global markets
- Designing manufacturing strategies that support scalable development, regulatory compliance, and seamless commercialisation across multiple geographies
- EW-001 armoured CAR-T case study highlighting regulatory considerations, operational efficiencies, and approaches to accelerate global development timelines
12:00 pm Panel Discussion: Why China, Why Now? Evaluating the Opportunities, Risks & Realities of Operating in China
- Assessing the advantages and trade-offs of Chinese development and manufacturing, to determine the optimal balance between speed, cost, quality, effort, and long-term clinical strategy
- Navigating IIT pathways and regulatory requirements to support future clinical and regulatory success in Asia, the US and Europe
- Examining the investment and commercial implications of conducting trials and manufacturing in China, to accelerate asset interest and global market opportunities
12:45 pm Lunch Break & Networking
Refuel over lunch while making the most of curated 1:1 meetings, available through our dedicated app. Connect directly with your key contacts and turn introductions into meaningful long-term relationships.
Engineering Cell Therapies to Combat the Tumour Microenvironment to Improve Long-Term Therapeutic Outcomes for Solid Tumour Therapies
1:45 pm Selectively & Safely Overcoming the Tumour Microenvironment to Reduce Barriers to Solid Tumour CAR-T Success
- Understanding solid tumour complexity and their microenvironment to enhance targeting and therapeutic outcomes
- Generating tumour-targeting immune cells tackling heterogeneity and immune suppression to overcome solid tumour defences
- Highlighting the precision and efficacy of HypoxiCAR in delivering highly potent payloads for neuroblastoma elimination
2:15 pm Advancing Novel CAR Therapies Through a Comprehensive Discovery Engine
- Identifying novel solid tumour targets through bioinformaticsdriven discovery to establish a strong foundation for CAR development
- Screening receptors and performing functional assays with patient-derived samples and in vitro models to select the optimal candidate for in vivo evaluation
- Evaluating data to select a candidate for preclinical development
Outlining Clinical Strategy for Emerging In Vivo & Ex Vivo Cell Therapies to Accelerate Clinical Approval
1:45 pm Accelerating Solid Tumour Cell Therapy Development Through Adaptive Trial Design & Regulatory Strategy
- Optimising eligibility criteria and patient selection strategies to enhance clinical outcomes and accelerate development in solid tumours
- Leveraging adaptive trial designs and proactive regulatory engagement to streamline development pathways and support faster approvals
- Showcasing Phase II clinical data and key learnings to refine development strategies and advance next-generation solid tumour cell therapies
2:15 pm Translating an iTANK-Enhanced CAR-T into the Clinic to Expand Treatment Opportunities for Glioblastoma Patients
- Exploring how the iTANK platform is designed to enhance anti-tumour immune responses and address the immunosuppressive tumour microenvironment
- Reviewing the clinical rationale and development strategy underpinning the advancement of ELC-401 into patient evaluation
- Presenting early clinical experience with iTANK-enhanced CAR-T therapy and its potential to address significant unmet need in glioblastoma
2:25 pm Afternoon Break & Poster Session
Contribute to the conversation and share your cutting-edge research with this community of cell therapy innovators while discovering exciting work carried out by your peers. To submit a poster, please contact info@hansonwade.com.
Boosting Novel Innovations to Deliver Safe Indication Expansion for Cell Therapies
3:45 pm Tailoring In Vivo Delivery Strategies for Autoimmune Disease Immunobiology
- Evaluating how viral vectors, lipid nanoparticles and other delivery platforms interact with hyperactive innate and adaptive immune systems to minimise unwanted inflammatory responses
- Exploring how cytokine release, macrophage activation and dendritic cell responses differ across lupus, systemic sclerosis, myositis and other autoimmune indications to address disease-specific safety considerations
- Moving beyond a one-size-fits-all approach to develop indication-specific delivery and dosing strategies to improve therapeutic activity while reducing toxicity risks
4:15 pm Demonstrating Clinical Success in Autoimmune Disease Through Safe & Effective B-Cell Reset Strategies
- Defining B-cell reset to achieve meaningful disease remission across autoimmune indications
- Highlighting the mechanistic basis of the safety behind Cabaletta’s rese-cel therapy to provide guidance on the development goals for autoimmune disease
4:45 pm Chair’s Closing Remarks
5:00 pm 10th CAR-TCR Anniversary Drinks Reception
Raise a glass to a decade of progress, partnerships, and innovation at the 10th Anniversary CAR-TCR Summit Europe. Reconnect with the scientific and strategic business leaders who have defined the European CAR and TCR market, revisit the data the sparked debate and continue the discussion that simply count not fit into a Q&A.