Hypoxia-Sensing CAR-T Cells for Treating Solid Cancers
Time: 2:15 pm
day: Day 2 - Track A - PM
Details:
- Introducing ‘HypoxiCAR’ a CAR-T platform which responds to hypoxia, a characteristic of most solid cancers, to express CAR molecules selectively in the tumour microenvironment
- We demonstrate the HypoxiCAR platform to be a sensitive and dynamic safety switch
- We demonstrate that hypoxia-sensing CAR-T cells effectively avoid the toxicities associated with on-target off-tumour activation in healthy tissues while delivering anti-tumour efficacy in pre-clinical models
