Overcoming CAR-T Toxicity with Next Generation T-Cell Reprogramming

Time: 1:30 pm
day: Day 1 – Track B – Afternoon


  • Highly potent and armoured CAR-T cells are necessary of inducing responses in solid tumours. This increases the risk of on-target off-tumour toxicity as well as severe immunotoxicity
  • Additionally, the unique solid tumour microenvironment can amplify cytokine release syndrome
  • We have engineered a next generation armoured CAR-T that has the potential to have lower risk of on-target off-tumour toxicity and severe immunotoxicity but with enhanced potential for efficacy